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Briefly, the animals were anesthetized with ketamine (0.5 mL/kg, im). The TCID50 10**−6 (4.0 mL/monkey) of the stock PUMC01 strain virus was sprayed into the nasal cavity of the animals. The peptide and/or peptide mixtures were dissolved as 480 μg/mL of each peptide in 0.9% NaCl and then formulated with an equal volume of Freund’s Complete Adjuvant (FCA) (Sigma, St. Louis, MO, USA) according to the manufacturer’s instructions. The injected dose of vaccine was 0.5 mL/4 kg/monkey (120 μg/4 kg/monkey) given through intramuscular (im) injections at four sites on the arms and legs.

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